基本信息
职称：教授
电话：021-31246639
邮箱：bkkuai@fudan.edu.cn
地址：复旦大学生命科学学院D413室

个人简介

      男，博士，复旦大学生命科学学院教授、生物化学与分子生物学专业博士生导师。英国威尔士大学生物工程学博士；英国草地环境研究所（BBSRC-IGER）博士后，美国杜克大学（Duke）访问教授。中国植物生理与分子生物学学会成熟与衰老专业委员会主任委员，上海市植物生理与分子生物学学会副理事长，上海市农业工程学会副理事长；上海市“农业遗传育种重点实验室”和“能源作物育种及应用重点实验室”学术委员会委员。
      本人领导的实验室在国际上率先克隆了绿色器官衰老进程中叶绿素降解的第一个关键酶基因NYEs/SGRs（孟德尔豌豆和大豆绿粒性状的调控因子）和第二个关键酶基因CRN1/PPH。揭示了主要植物激素和光信号调控叶绿素降解和叶片衰老的多个关键调控路径。

主要研究方向 (Research Interests)
1）蔬果成熟过程中营养成分/风味物质形成的调控机理
      主要探索番茄、水果玉米和草莓等生食蔬果成熟过程中营养成分/风味物质形成的协同调控机理。生食蔬果是健康营养物质的主要来源之一，长期以提高产量与效益为主的品种改良使得其营养品质和风味口感大大降低。我们以遗传学、分子生物学和代谢组学等手段研究其营养成分/风味物质形成的遗传基础和分子机理，并探索其改良路径。
2）绿色器官成熟衰老进程中叶绿素降解的调控机理
      重点研究主要植物激素调控绿色器官成熟衰老进程中叶绿素降解的特异性及其关联调控关系。我们借助于拟南芥模式体系，利用分子生物学、基因组学和生物信息学等技术手段，系统研究了绿色器官衰老的关键生化事件---叶绿素降解启动的信号与关键调控节点，并解析了与叶片衰老进程关联调控的网络关系。
3）叶片衰老与抗逆性之间的协同调控机理
      试图阐释叶片衰老与抗旱性/抗病性之间的协同调控关系。植物的自养属性和固着生活方式决定了其叶片在营养运筹方面的双重功能：发育成熟的叶片营光合同化功能，而在遭遇逆境胁迫启动衰老时叶片则营营养物质的再动员功能。叶片衰老的适时启动，使得其同化能力和营养物质再动员能力双双达到最大化，不仅能够保障植株生长发育的竞争优势，也能够有助于作物产量和品质的提高。

获奖情况 (Awards)
1）主持培育出了衰老叶片不黄化和抵抗锈病的草坪草新品种“滞绿1号”，获得上海市优秀发明选拔赛一等奖（2004年）；
2）曾获上海市优秀青年教师和曙光学者称号；
3）曾被委任为上海市科委重大攻关研究计划《重要转基因作物安全性研究》首席专家和上海市科技发展重点领域技术预见专家（三任）。

代表性成果
1. Li Z, Wu S, Chen J, Wang X, Gao J, Ren G*, Kuai B* (2017) NYEs/SGRs-mediated chlorophyll degradation is critical for detoxification during seed maturation in Arabidopsis. Plant J. 92:650-661
2. Chen J, Zhu X, Ren J, Qiu K, Li Z, Xie Z, Gao J, Zhou X*, Kuai B* (2017) Suppressor of Overexpression of CO 1 negatively regulates dark-induced leaf degreening and senescence by directly repressing pheophytinase and other senescence-associated genes in Arabidopsis. Plant Physiol. 173(3):1881-1891
3. Gao S, Gao J, Zhu X, Song Y, Li Z, Ren G, Zhou X*, Kuai B* (2016) ABF2, ABF3, and ABF4 promote ABA-mediated chlorophyll degradation and leaf senescence by transcriptional activation of chlorophyll catabolic genes and senescence-associated genes in Arabidopsis. Mol. Plant 9(9):1272-1285
4. Wu S, Li Z, Yang L, Xie Z, Chen J, Zhang W, Liu T, Gao S, Gao J, Zhu Y, Xin J, Ren G*, Kuai B* (2016) NON-YELLOWING2 (NYE2), a close paralog of NYE1, plays a positive role in chlorophyll degradation in Arabidopsis. Mol. Plant 9(4):624-627
5. Li Z, Wang X, Chen J, Gao J, Zhou X*, Kuai B* (2016) CCX1, a putative cation / Ca2+ exchanger, participates in the regulation of reactive oxygen species homeostasis and leaf senescence. Plant and Cell Physiol. 57 (12):2611-2619
6. Li S, Gao J, Yao L, Ren G, Zhu X, Gao S, Qiu K, Zhou X*, Kuai B* (2016) The role of ANAC072 in the regulation of chlorophyll degradation during age- and dark-induced leaf senescence. Plant Cell Rep. 35 (8):1729-1741
7. Zhu X, Chen J, Xie Z, Gao J, Ren G, Gao S, Zhou X*, Kuai B* (2015) Jasmonic acid promotes degreening via MYC2/3/4- and ANAC019/055/072-mediated regulation of major chlorophyll catabolic genes. Plant J. 84:597-610
8. Qiu K, Li Z, Yang Z, Chen J, Wu S, Zhu X, Gao S, Gao J, Ren G, Kuai B*, Zhou X* (2015) EIN3 and ORE1 accelerate degreening during ethylene-mediated leaf senescence by directly activating chlorophyll catabolic genes in Arabidopsis. PLoS Genet. 11(7): e1005399 doi:10.1371/journal.pgen.1005399
9. Wang X, Gao J, Zhu Z, Dong X, Wang X, Ren G, Zhou X*, Kuai B*（2015） TCP transcription factors are critical for the coordinated regulation of ISOCHORISMATE SYNTHASE 1 expression in Arabidopsis thaliana. Plant J. 82:151-162
10. Song Y, Yang C, Gao S, Zhang W, Li L*, Kuai B*(2014) Age-Triggered and Dark-Induced leaf senescence require the bHLH transcription factors PIF3, 4 and 5. Mol. Plant 7:1776-1787
11. Ren G, Zhou Q, Wu S, Zhang Y, Zhang L, Huang J, Sun Z, Kuai B*（2010）Reverse genetic identification of CRN1 and its distinctive role in chlorophyll degradation in Arabidopsis. J. Integr. Plant Biol. 52 (5):496-504
12. Ren G, An K, Liao Y, Zhou X, Cao Y, Zhao H, Ge X, Kuai B*（2007） Identification of a novel chloroplast protein AtNYE1 regulating chlorophyll degradation during leaf senescence in Arabidopsis. Plant Physiol. 144:1429-1441
13. Liao Y, An K, Zhou X, Chen W, Kuai B*（2007）AtCLH2, a typical but possibly distinctive chlorophyllase gene in Arabidopsis. J. Integr. Plant Biol. 49 (4):531-539
14. Liao Y, Zhou X, Yu J, Cao Y, Li X, Kuai B*（2006）The key role of chlorocatechol 1,2-dioxygenase in phytoremoval and degradation of catechol by transgenic Arabidopsis. Plant Physiol. 142:620-628
15. Cao S, Xu Q, Cao Y, Qian K, An K, Zhu Y, Hu B, Zhao H, Kuai B*（2005）Loss-of-function mutations in det2 gene lead to an enhanced resistance to oxidative stress in Arabidopsis. Physiologia Plantarum 123 (1):57-66
16. Zhu Y, Zhao H, Ren G, Yu X, Kuai B*（2005）Characterization of a novel developmentally retarded mutant (drm1) associated with the autonomous flowering pathway in Arabidopsis. Cell Research 15(2):133-140
 

• 综述与评述

1. Kuai B, Chen J, Hörtensteiner S* (2018) The biochemistry and molecular biology
of chlorophyll breakdown, J EXP BOT. 69(4):751-767
2. Zhu X, Chen J, Qiu K, Kuai B* (2017) Phytohormone and light regulation of chlorophyll degradation. Front Plant Sci, doi: 10.3389/fpls.2017.01911
3. Chen J, Ren G, Kuai B* (2016) The Mystery of Mendel's stay-green: magnesium stays chelated in chlorophylls. Mol. Plant 9(12):1556-1558